The Correlations between Horizontal and Vertical Peripheral Refractions and Human Eye Shape Using Magnetic Resonance Imaging in Highly Myopic Eyes

The aim of this study was to determine the relationship between relative peripheral refraction and retinal shape by 2-D magnetic resonance imaging in high myopes. Thirty-five young adults aged 20 to 30 years participated in this study with 16 high myopes (spherical equivalent < -6.00 D) and 19 emmetropes (+0.50 to -0.50 D). An open field autorefractor was used to measure refractions from the center out to 60 degrees in the horizontal meridian and out to around 20 degrees in the vertical meridian, with a step of 3 degrees. Axial length was measured by using A-scan ultrasonography. In addition, images of axial, sagittal, and tangential sections were obtained using 2-D magnetic resonance imaging. The highly myopic group had a significantly relative peripheral hyperopic refraction and showed a prolate ocular shape compared to the emmetropic group. The highly myopic group had relative peripheral hyperopic refraction and showed a prolate ocular form. Significant differences in the ratios of height/axial (1.01 +/- 0.02 vs. 0.94 +/- 0.03) and width/axial (0.99 +/- 0.17 vs. 0.93 +/- 0.04) were found from the MRI images between the emmetropic and the highly myopic eyes (p < 0.001). There was a negative correlation between the retina's curvature and relative peripheral refraction for both temporal (Pearson r = -0.459; p < 0.01) and nasal (Pearson r = -0.277; p = 0.011) retina. For the highly myopic eyes, the amount of peripheral hyperopic defocus is correlated to its ocular shape deformation. This could be the first study investigating the relationship between peripheral refraction and ocular dimension in high myopes, and it is hoped to provide useful knowledge of how the development of myopia changes human eye shape.

Automated summary

The study investigated the relationship between relative peripheral refraction and retinal shape using 2-D magnetic resonance imaging in high myopes. The highly myopic group showed relative peripheral hyperopic refraction and a prolate ocular shape compared to emmetropes. There was a negative correlation between retina's curvature and relative peripheral refraction, and the amount of peripheral hyperopic defocus in highly myopic eyes was related to ocular shape deformation.