4.4 Review

Alphaviruses: Host pathogenesis, immune response, and vaccine & treatment updates

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Review Microbiology

Insights into Antibody-Mediated Alphavirus Immunity and Vaccine Development Landscape

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Summary: Alphaviruses are mosquito-borne pathogens that can cause a wide range of symptoms, including arthritis and encephalitis. Susceptible populations historically develop long-lasting antibody responses after large outbreaks, indicating the potential for vaccines. However, little is known about humoral responses triggered by other emerging alphaviruses, which is crucial for improving diagnostics and vaccine development.

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Characterisation of the Semliki Forest Virus-host cell interactome reveals the viral capsid protein as an inhibitor of nonsense-mediated mRNA decay

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Summary: Understanding the interactions between Semliki Forest Virus proteins and host cell proteins is crucial for understanding the mechanisms by which the virus replicates successfully and develops specific antiviral interventions. The study shows that the virus hijacks the translation machinery and inhibits NMD to escape the host cell's defense mechanisms, with the capsid protein playing a key role in inhibiting NMD during the infectious cycle.

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Activation of the PI3K-AKT Pathway by Old World Alphaviruses

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The NF-κB/leukemia inhibitory factor/STAT3 signaling pathway in antibody-mediated suppression of Sindbis virus replication in neurons

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Src Family Kinase Inhibitors Block Translation of Alphavirus Subgenomic mRNAs

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RNA processing bodies are disassembled during Old World alphavirus infection

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Self-Amplifying RNA Vaccines for Venezuelan Equine Encephalitis Virus Induce Robust Protective Immunogenicity in Mice

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Current Strategies for Inhibition of Chikungunya Infection

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Vaccine and Therapeutic Options To Control Chikungunya Virus

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Inflammatory monocytes mediate control of acute alphavirus infection in mice

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Vector-delivered artificial miRNA effectively inhibited replication of Chikungunya virus

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Eastern Equine Encephalitis Treated With Intravenous Immunoglobulins

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Arbovirus in Latin America

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Replicon RNA Viral Vectors as Vaccines

Kenneth Lundstrom

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Towards antivirals against chikungunya virus

Rana Abdelnabi et al.

ANTIVIRAL RESEARCH (2015)

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Chikungunya: Evolutionary history and recent epidemic spread

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Review Biochemistry & Molecular Biology

Arthritogenic alphaviruses: new insights into arthritis and bone pathology

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Chikungunya Virus Pathogenesis and Immunity

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CD8+ T Cells Control Ross River Virus Infection in Musculoskeletal Tissues of Infected Mice

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Toll-Like Receptors in Antiviral Innate Immunity

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Cytokines in Acute Chikungunya

Anuradha Venugopalan et al.

PLOS ONE (2014)

Article Multidisciplinary Sciences

Interleukin 10 modulation of pathogenic Th17 cells during fatal alphavirus encephalomyelitis

Kirsten A. Kulcsar et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

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A Viral RNA Structural Element Alters Host Recognition of Nonself RNA

Jennifer L. Hyde et al.

SCIENCE (2014)

Article Infectious Diseases

Multiple Immune Factors Are Involved in Controlling Acute and Chronic Chikungunya Virus Infection

Yee Suan Poo et al.

PLOS NEGLECTED TROPICAL DISEASES (2014)

Review Pharmacology & Pharmacy

Chikungunya fever: Epidemiology, clinical syndrome, pathogenesis and therapy

Simon-Djamel Thiberville et al.

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Article Infectious Diseases

Prolonged polyarthralgia in a German traveller with Mayaro virus infection without inflammatory correlates

Christian Theilacker et al.

BMC INFECTIOUS DISEASES (2013)

Article Biochemistry & Molecular Biology

Species-specific impact of the autophagy machinery on Chikungunya virus infection

Delphine Judith et al.

EMBO REPORTS (2013)

Article Immunology

An Essential Role of Antibodies in the Control of Chikungunya Virus Infection

Fok-Moon Lum et al.

JOURNAL OF IMMUNOLOGY (2013)

Article Virology

Dendritic Cell Immunoreceptor Regulates Chikungunya Virus Pathogenesis in Mice

Kristin M. Long et al.

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Infection of Aedes albopictus with Chikungunya Virus Rectally Administered by Enema

John T. Nuckols et al.

VECTOR-BORNE AND ZOONOTIC DISEASES (2013)

Article Public, Environmental & Occupational Health

Cytokine levels in patients with chikungunya virus infection

Chintana Chirathaworn et al.

ASIAN PACIFIC JOURNAL OF TROPICAL MEDICINE (2013)

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Effective Chikungunya Virus-like Particle Vaccine Produced in Insect Cells

Stefan W. Metz et al.

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Molecular Mechanisms Involved in the Pathogenesis of Alphavirus-Induced Arthritis

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Early Events in Alphavirus Replication Determine the Outcome of Infection

Ilya Frolov et al.

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Arthritogenic alphaviruses-an overview

Andreas Suhrbier et al.

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Chikungunya Disease: Infection-Associated Markers from the Acute to the Chronic Phase of Arbovirus-Induced Arthralgia

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Alphavirus Entry: NRAMP Leads the Way

Katie M. Stiles et al.

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Rui Zhang et al.

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Recruited inflammatory monocytes stimulate antiviral Th1 immunity in infected tissue

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Chikungunya disease in nonhuman primates involves long-term viral persistence in macrophages

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Isolation and Phylogenetic Analysis of Sindbis Viruses from Mosquitoes in Germany

Hanna Joest et al.

JOURNAL OF CLINICAL MICROBIOLOGY (2010)

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Chikungunya Virus Arthritis in Adult Wild-Type Mice

Joy Gardner et al.

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Atypical manifestations of chikungunya infection

Senaka Rajapakse et al.

TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE (2010)

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Arboviral Etiologies of Acute Febrile Illnesses in Western South America, 2000-2007

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INDIAN JOURNAL OF PEDIATRICS (2009)

Article Immunology

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Therese Couderc et al.

MICROBES AND INFECTION (2009)

Article Immunology

Vaccines for Venezuelan equine encephalitis

Slobodan Paessler et al.

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Replication cycle of chikungunya: A re-emerging arbovirus

Maxime Solignat et al.

VIROLOGY (2009)

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Persistent arthralgia associated with chikungunya virus: A study of 88 adult patients on Reunion Island

Gianandrea Borgherini et al.

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Kate D. Ryman et al.

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Eryu Wang et al.

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RNA interference-mediated inhibition of semliki forest virus replication in mammalian cells

Attila A. Seyhan et al.

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PLOS PATHOGENS (2007)

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Neuroprotective interventions targeting detrimental host immune responses protect mice from fatal alphavirus encephalitis

David N. Irani et al.

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2007)

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TRENDS IN IMMUNOLOGY (2005)

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Early events in the pathogenesis of eastern equine encephalitis virus in mice

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A Suhrbier et al.

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