Advancement of Chiral Monodentate Phosphite Ligands in Asymmetric Hydrogenation

Since the 21st century, the study of chiral monophosphorous ligands, especially chiral mono-phosphites ligands and mono-phosphoramidites ligands has attracted widespread attention. This kind of ligands was extensively used in various asymmetric catalytic reactions, for most of them were easily synthesized and showed good stability, high activity and high enantioselectivity. The diverse common monodentate phosphonites, phosphites, and phosphoramidites ligands and their applications in asymmetric hydrogenations over the past two decades are reviewed.

Automated summary

The study of chiral monophosphorous ligands, especially chiral mono-phosphites ligands and mono-phosphoramidites ligands, has attracted widespread attention since the 21st century. These ligands are widely used in various asymmetric catalytic reactions for their ease of synthesis and excellent stability, activity, and enantioselectivity. The diverse common monodentate phosphonites, phosphites, and phosphoramidites ligands and their applications in asymmetric hydrogenations have made significant progress over the past two decades.