期刊
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
卷 2017, 期 39, 页码 5872-5879出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.201700899
关键词
Fluorinated compounds; Cyclopropanols; Fluorine; Ketones; Oxidation; Silver
资金
- UIC Department of Chemistry
- National Science Foundation (CAREER Award) [1654490]
- Division Of Chemistry
- Direct For Mathematical & Physical Scien [1654490] Funding Source: National Science Foundation
A regioselective synthesis of beta-fluorinated ketones by silver(II)-mediated ring opening is described. Commercially available AgF2 serves as both an oxidant and fluorine-atom source. A variety of beta-fluorinated ketones are efficiently prepared from tertiary cyclopropanol precursors, offering a straightforward approach for the introduction of a fluorine atom at a remote site. Selectivity is observed in the site of bond cleavage, which leads to fluorination at the more substituted site. A radical mediated sequential homolytic C-C bond cleavage and C-F bond formation is suggested.
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