期刊
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
卷 2018, 期 5, 页码 605-613出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.201701110
关键词
NMR spectroscopy; Oligonucleotides; Nucleosides; Isotopic labeling
资金
- Academy of Finland [251539, 256214]
- EXPERT Sustain program
Phosphoramidite building blocks of CF3-modified N-4(6-amino-2-pyridinyl)deoxycytidines were synthesized, incorporated into triplex-forming 2-deoxyoligonucleotide strands and the applicability of the probes to recognize nucleobase content in the pyrimidine-rich strand of double-helical DNA targets was evaluated. As expected, the obtained F-19 NMR resonances were sensitive to the base content and unique F-19 NMR spectral fingerprints could be obtained.
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