期刊
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
卷 2017, 期 44, 页码 6533-6539出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.201700871
关键词
Continuous flow; Diazo compounds; Flow Chemistry; Synthetic methods
资金
- Science Foundation Ireland [SFI 15/RI/3221]
- European Regional Development Fund [SFI SSPC2 12/RC/2275]
The hazardous diazo transfer reagent mesyl azide has been safely generated and used in situ for continuous diazo transfer as part of an integrated synthetic process with an embedded safety quench. Diazo transfer to -keto esters and a -ketosulfone was successful. In-line phase separation, by means of a continuous liquid-liquid separator, enabled direct telescoping with a thermal Wolff rearrangement.
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