期刊
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
卷 2018, 期 8, 页码 957-970出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.201701250
关键词
Synthetic methods; Domino reactions; One-pot reaction; Acylation; Quinolinones; Nitrogen heterocycles
资金
- Council of Scientific and Industrial Research (CSIR), New Delhi [02(0262)/16/EMR-II]
- MHRD, New Delhi
Pd-catalyzed direct acylation reaction of iodoacetanilides/iodophenyl acetates with aldehydes is presented. Simple, bench-top aldehydes were used as non-toxic acylating agents. This protocol comprises direct coupling with aldehydes without activating the carbonyl group and without directing group assistance. The strategy was applied to a domino one-pot synthesis of 2-quinolinones through acylation and intramolecular aldol condensation. Significantly, the strategy was extended to the domino one-pot synthesis of drugs and bioactive compounds.
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