期刊
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
卷 2017, 期 13, 页码 1713-1720出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.201601616
关键词
Bile acids; Amino acids; Supramolecular chemistry; X-ray crystallography; Gels
资金
- Department of Science & Technology, New Delhi [SR/S1/OC-68/2011]
- Department of Science and Technology (DST)
- Council of Scientific and Industrial Research (CSIR)
Hydrogels composed of low molecular weight molecules are gaining increasing importance in biomedical applications. In this work, we report the formation of injectable hydrogels from bile acid-amino acid conjugates. The hydrogelation ability was dependent on multiple factors such as the bile acid backbone, linkage between the bile acid and the amino acid, and pH. We have shown that the gelation properties depend on multiple noncovalent interactions and on the balance between hydrophobic and hydrophilic characteristics of the molecules. Crystal structures of lithocholyl-L-phenylalanine, lithocholylglycine, lithocholyl-L-valine, and lithocholyl-L-alanine were also determined and compared. Finally, the rigid hydrogel frameworks were utilized to produce inorganic-organic composite materials with gold and ZnO nanoparticles.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据