KOtBu-Mediated Domino Isomerization and Functionalization of Aromatic Allylic Alcohols

Transition-metal-as well as ligand-free base-mediated domino isomerization and alkylation of allylic alcohols is presented. This protocol features the conversion of simple allylic alcohols into the corresponding ketones through isomerization in the presence of a simple base. Significantly, these in situ generated ketones subsequently undergo alkylation with styrenes as electrophiles, in a domino one-pot fashion, as an atom-and step-economical chemical process.