期刊
RSC CHEMICAL BIOLOGY
卷 2, 期 6, 页码 -出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1cb00147g
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资金
- Institute for Basic Science (IBS) [IBSR007-A1]
- National Research Foundation of Korea (NRF) - Korea government (MSIT) [2020R1A2C2009776]
- National Research Foundation of Korea (NRF) - Ministry of Education [2020R1A6A1A03047902]
- National Research Foundation of Korea [2020R1A2C2009776] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
The molecular targets of CDy1, ALDH2 and ABCB1, were identified through live-cell affinity-matrix and ABC transporter CRISPRa library screening, revealing the potential for multi-dimensional cellular distinction of specific cell types.
CDy1 is a powerful tool to distingusih embryonic stem cells for reprogramming studies and regeneration medicine. However, the stem cell selectivity mechanism of CDy1 has not been fully understood. Here, we report ALDH2 and ABCB1 as the molecular targets of CDy1, elucidated by live-cell affinity-matrix and ABC transporter CRISPRa library screening. The two unique orthogonal mechanisms provide the potential of multi-demensional cellular distinction of specific cell types.
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