Hypoxia and the Tumor Microenvironment

Hypoxia is an important feature of the tumor microenvironment, and is closely associated with cell proliferation, angiogenesis, metabolism and the tumor immune response. All these factors can further promote tumor progression, increase tumor aggressiveness, enhance tumor metastatic potential and lead to poor prognosis. In this review, these effects of hypoxia on tumor biology will be discussed, along with their significance for tumor detection and treatment.

Automated summary

Hypoxia is a key feature of the tumor microenvironment, closely associated with cell proliferation, angiogenesis, metabolism, and the tumor immune response. These effects of hypoxia can further promote tumor progression, aggressiveness, metastatic potential, and lead to poor prognosis.