期刊
COMPUTERS IN BIOLOGY AND MEDICINE
卷 65, 期 -, 页码 229-242出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.compbiomed.2015.04.027
关键词
Conduction velocity; Cardiac electrophysiology; Local activation time; Cardiac mapping; Arrhythmias
类别
资金
- British Heart Foundation (BHF) [FS/11/22/28745, RG/10/11/28457]
- EPSRC [EP/K038788/1]
- Imperial BHF Centre of Research Excellence
- Academy of Medical Sciences Starter Grant [AMS-SGCL8-Ng]
- National Institute of Health Research Clinical Lectureship [LDN/007/255/A]
- NIHR Biomedical Research Centre
- ElectroCardioMaths programme, part of the Imperial BHF Centre of Research Excellence
- Academy of Medical Sciences (AMS) [AMS-SGCL8-Ng] Funding Source: researchfish
- British Heart Foundation [RG/10/11/28457, FS/11/22/28745, FS/11/69/29017] Funding Source: researchfish
- Engineering and Physical Sciences Research Council [EP/K038788/1] Funding Source: researchfish
- Medical Research Council [G0900396] Funding Source: researchfish
- National Institute for Health Research [CL-2011-21-001] Funding Source: researchfish
- EPSRC [EP/K038788/1] Funding Source: UKRI
- MRC [G0900396] Funding Source: UKRI
Measurements of cardiac conduction velocity provide valuable functional and structural insight into the initiation and perpetuation of cardiac arrhythmias, in both a clinical and laboratory context. The interpretation of activation wavefronts and their propagation can identify mechanistic properties of a broad range of electrophysiological pathologies. However, the sparsity, distribution and uncertainty of recorded data make accurate conduction velocity calculation difficult. A wide range of mathematical approaches have been proposed for addressing this challenge, often targeted towards specific data modalities, species or recording environments. Many of these algorithms require identification of activation times from electrogram recordings which themselves may have complex morphology or low signal-to-noise ratio. This paper surveys algorithms designed for identifying local activation times and computing conduction direction and speed. Their suitability for use in different recording contexts and applications is assessed. (C) 2015 The Authors. Published by Elsevier Ltd.
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