期刊
JOURNAL OF INFECTIOUS DISEASES
卷 223, 期 12, 页码 2108-2112出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jiaa697
关键词
cytomegalovirus; sepsis; mechanical ventilation; critical illness
资金
- National Institutes of Health/National Institute of Allergy and Infectious Diseases [T32 AI118690-03, R56 AI140953, K24 HL09329410, U01 HL102547-01, HHSN272201600016C, HHSN272201100041C, HHSN272201600019C]
- Merck
The study found that CMV reactivation is independently associated with clinical outcomes in ICU patients with sepsis, with potential effect sizes that could serve as endpoints for future interventional trials.
We performed multivariable analysis of potential risk factors (including cytomegalovirus [CMV] reactivation) for clinical outcomes by day 28 (death or continued hospitalization, ventilator-free days, intensive care unit (ICU)-free days, hospital-free days) from pooled cohorts of 2 previous prospective studies of CMV-seropositive adults with sepsis. CMV reactivation at any level, >100 IU/mL, >1000 IU/mL, peak viral load, and area under the curve were independently associated with the clinical outcomes. We identified the potential effect size of CMV on outcomes that could be used as end points for future interventional trials of CMV prevention using antiviral prophylaxis in ICU patients with sepsis.
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