期刊
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
卷 211, 期 -, 页码 108-111出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ejogrb.2017.02.015
关键词
Dienogest; Deep infiltrating endometriosis; Quality of life; Pelvic pain; Clinical treatment
Objective: To evaluate the effectiveness of dienogest in controlling pain caused by deep infiltrating endometriosis (DIE), its influence on the quality of live (QoL) of women affected by the disease, and the effect of the drug on the volume of endometriotic lesions. Study design: A prospective cohort study including 30 women with a sonographic diagnosis of DIE (intestinal and posterior fornix) treated with dienogest 2 mg per day for 12 months. We evaluated the pain symptoms and the volume of the intestinal and posterior fornix lesions before and after 12 months of use of dienogest. To perform the statistical analysis, we used the Wilcoxon signed-rank test, and the relationship between the data was tested using the Spearman correlation coefficient. Results: Women were on average 36.13 +/- 6.24 years old. Pain symptoms most commonly reported were dyspareunia (83.3%), dysmenorrhea (73.3%), and pelvic pain (66.7%). After 12 months of treatment with dienogest, there was significant improvement of various symptoms (dyspareunia p = 0.0093, dysmenorrhea p < 0.0001; pelvic pain p = 0.0007; and bowel pain p < 0.0001), without a reduction in the volume of endometriotic nodules. There were significant improvements in the parameters that comprise the QoL (physical p < 0.0001; p = 0.0007 psychological) and the self-assessment of QoL (p = 0.0069) and health (p = 0.0001). Conclusion: Dienogest is an effective medication to control symptoms of pain related to DIE, even without reducing the volume of DIE nodules. (C) 2017 Elsevier B.V. All rights reserved.
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