期刊
EUROPEAN JOURNAL OF NUTRITION
卷 57, 期 8, 页码 3003-3005出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s00394-017-1600-2
关键词
MR spectroscopy; Guanidinoacetic acid; Glutamate; Supplementation
资金
- Serbian Ministry of Education, Science and Technological Development [175037]
- Provincial Secretariat for Higher Education and Scientific Research [114-451-710]
- Center for Health, Exercise and Sport Sciences
We conducted a secondary analysis of a previously completed trial to determine the effects of 8-week guanidinoacetic acid (GAA) loading on brain GAA levels in five healthy men. Brain magnetic resonance spectroscopy (1H-MRS) was taken at baseline and post-administration, with spectra additionally analyzed for brain GAA and glutamate concentrations using TARQUIN 4.3.10 software. Brain GAA levels remained essentially unchanged at follow-up (an increase of 7.7% from baseline levels; 95% confidence interval, - 24.1% to 39.5%; P = 0.88) when averaged across 12 white and grey matter voxel locations. No significant changes were found for brain glutamate levels during the study (P = 0.64). Supplemental GAA appears to be safe intervention concerning brain GAA deposition, at least with GAA dosages used.
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