期刊
EUROPEAN JOURNAL OF NEUROSCIENCE
卷 47, 期 10, 页码 1148-1158出版社
WILEY
DOI: 10.1111/ejn.13638
关键词
dopamine; dyskinesia; electrophysiology; G-protein-coupled receptor; neuromodulation; striatum
资金
- NIH [R01 NS034696]
- JPB Foundation
- IDP Foundation
- Michael J. Fox Foundation
- Parkinson Disease Foundation
- Flanagan Scholars program
Giant, aspiny cholinergic interneurons (ChIs) have long been known to be key nodes in the striatal circuitry controlling goal-directed actions and habits. In recent years, new experimental approaches, like optogenetics and monosynaptic rabies virus mapping, have expanded our understanding of how ChIs contribute to the striatal activity underlying action selection and the interplay of dopaminergic and cholinergic signaling. These approaches also have begun to reveal how ChI function is distorted in disease states affecting the basal ganglia, like Parkinson's disease (PD). This review gives a brief overview of our current understanding of the functional role played by ChIs in striatal physiology and how this changes in PD. The translational implications of these discoveries, as well as the gaps that remain to be bridged, are discussed as well.
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