期刊
EUROPEAN JOURNAL OF NEUROSCIENCE
卷 46, 期 11, 页码 2754-2767出版社
WILEY
DOI: 10.1111/ejn.13766
关键词
hippocampal neurons; invitro interactions; microtubules; plasma membrane; vesicles; yeast two-hybrid
资金
- French National Research Agency [2010 Blanc 120201 CBioS]
MAP6 proteins were first described as microtubule-stabilizing agents, whose properties were thought to be essential for neuronal development and maintenance of complex neuronal networks. However, deletion of all MAP6 isoforms in MAP6 KO mice does not lead to dramatic morphological aberrations of the brain but rather to alterations in multiple neurotransmissions and severe behavioural impairments. A search for protein partners of MAP6 proteins identified Tctex1 - a dynein light chain with multiple non-microtubule-related functions. The involvement of Tctex1 in calcium signalling led to investigate it in MAP6 KO neurons. In this study, we show that functional Ca(v)2.2/N-type calcium channels are deficient in MAP6 KO neurons, due to improper location. We also show that MAP6 proteins interact directly with both Tctex1 and the C-terminus of Ca(v)2.2/N-type calcium channels. A balance of these two interactions seems to be crucial for MAP6 to modulate calcium signalling in neurons.
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