期刊
EUROPEAN JOURNAL OF NEUROSCIENCE
卷 45, 期 6, 页码 837-845出版社
WILEY
DOI: 10.1111/ejn.13508
关键词
electroencephalography; motor cortex; partial least squares; plasticity; transcranial magnetic stimulation
资金
- Physiotherapy Research Foundation grant [S15-009]
- National Health and Medical Research Council of Australia [1072057]
- NHMRC-ARC Dementia Research Development Fellowship [1102272]
- National Health and Medical Research Council of Australia [1102272] Funding Source: NHMRC
Responses to non-invasive brain stimulation are highly variable between subjects. Resting state functional connectivity was investigated as a marker of plasticity induced by anodal transcranial direct current stimulation (tDCS). Twenty-six healthy adults (15 male, 26.4 +/- 6.5years) were tested. Experiment 1 investigated whether functional connectivity could predict modulation of corticospinal excitability following anodal tDCS. Experiment 2 determined test-retest reliability of connectivity measures. Three minutes of electroencephalography was recorded and connectivity was quantified with the debiased weighted phase lag index. Anodal (1mA, 20min) or sham tDCS was applied to the left primary motor cortex (M1), with a change in motor evoked potential amplitude recorded from the right first dorsal interosseous used as a marker of tDCS response. Connectivity in the high beta frequency (20-30Hz) between an electrode approximating the left M1 (C3) and electrodes overlying the left parietal cortex was a strong predictor of tDCS response (cross-validated R-2=0.69). Similar relationships were observed for alpha (8-13Hz; R-2=0.64), theta (4-7Hz; R-2=0.53), and low beta (14-19Hz; R-2=0.58) frequencies, however, test-retest reliability of connectivity measures was strongest for the high beta frequency model (ICC=0.65; good reliability). Further investigation of the high beta model found that greater connectivity between C3 and a cluster of electrodes approximately overlying the left parietal cortex was associated with stronger responses to anodal (rho=0.61, P=0.03), but not sham tDCS (rho=0.43, P=0.14). Functional connectivity is a strong predictor of the neuroplastic response to tDCS and may be one important characteristic to assist targeted tDCS application.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据