期刊
ADIPOCYTE
卷 10, 期 1, 页码 435-445出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/21623945.2021.1965314
关键词
Adipose tissue inflammation; cd4(+) t cells; cd8(+) t cells; treg cells
资金
- National Natural Science Foundation of China [81672264]
Studies have shown that T cells, including Th1, Th17, CD8(+) T cells, and Treg cells, play significant roles in regulating adipose tissue inflammation in obese patients. Therapeutic strategies targeting the mechanisms by which these T cell subtypes regulate inflammation may provide new directions for treating obesity, with further research needed to identify potential treatments.
Adipose tissue inflammation in obese patients can cause a series of metabolic diseases. There are a variety of immune cells in adipose tissue, and studies have shown that T cells are associated with adipose tissue inflammation. This review aims to describe the current understanding of the relationship between T cells and adipose tissue inflammation, with a focus on regulation by T cell subtypes. Studies have shown that Th1, Th17 and CD8(+) T cells, which are important T cell subsets, can promote the development of adipose tissue inflammation, whereas Treg cells protect against inflammation, suggesting that targeting the mechanism by which T cell subtypes regulate adipose tissue inflammation is a potential therapeutic strategy for treating obesity. T cells play important roles in regulating obesity-associated adipose tissue inflammation, thus providing new research directions for the treatment of obesity. More studies are needed to clarify how T cell subtypes regulate adipose tissue inflammation to identify new treatments for obesity.
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