期刊
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
卷 137, 期 -, 页码 292-309出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2017.06.002
关键词
Isoxazole; Substituted isoxazoles; Chemical synthesis; Therapeutic agents
资金
- Wroclaw Centre of Biotechnology, programme Leading National Research Centre (KNOW) [14/2017]
Due to its relatively easy synthesis, isoxazole ring has been as an object of interest for chemists and pharmacologists from research groups all over the world. Its chemical modifications include both connection of isoxazole with other aromatic, heteroaromatic or non aromatic rings and substitution with different alkyl groups. Thanks to their usually low cytotoxicity, isoxazole derivatives are still popular scaffolds for the development of new agents with variable biological activities, such as antimicrobial, antiviral, anticancer, anti-inflammatory, immunomodulatory, anticonvulsant or anti-diabetic properties. This review discusses the chemical structure of recently developed isoxazole derivatives with regards to their activity and potential therapeutic use. (C) 2017 Elsevier Masson SAS. All rights reserved.
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