期刊
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
卷 142, 期 -, 页码 393-415出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2017.08.049
关键词
Antibody-drug conjugate; Albumin-drug conjugate; Prodrug; Glucuronide; Matrix metalloproteinase; Chemotherapy; Cancer; Tumor targeting
资金
- French National Research Agency under the program Investissements d'avenir Grant Agreement LabEx MAbImprove [ANR-10-LABX-53-01]
- Tours University
- CNRS
- La Ligue contre le Cancer [Comites 44, 79, 85]
- ANR-LABEX MAbImprove
The design of innovative anticancer chemotherapies with superior antitumor efficacy and reduced toxicity continues to be a challenging endeavor. Recently, the success of Adcetris (R) and Kadcyla (R) made antibody-drug conjugates (ADCs) serious contenders to reach the envied status of Paul Ehrlich's magic bullet. However, ADCs classically target overexpressed and internalizing antigens at the surface of cancer cells, and in solid tumors are associated with poor tumor penetration, insufficient targeting in heterogeneous tumors, and appearance of several resistance mechanisms. In this context, alternative non-internalizing ADCs and prodrugs have been developed to circumvent these limitations, in which the drug can be selectively released by an extracellular stimulus in the tumor microenvironment. Each strategy and method of activation will be discussed as potential alternatives to internalizing ADCs for cancer therapy. (C) 2017 Elsevier Masson SAS. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据