期刊
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
卷 138, 期 -, 页码 182-198出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2017.06.032
关键词
Antialzheimer; Anticancer; Antimicrobial; Antiviral; Indanone; Pharmaceutical agent
资金
- DST-SERB, India [SERB/F/7013/2015-16]
- DST-Nanomission, India [SR/NM/NS-20/2014]
- Jain University
Indanone is one of the privileged structures in medicinal chemistry and it's commonly associated with various pharmacologically active compounds. The indanone moiety is found in several natural compounds and also, it can be used as intermediate in the synthesis of many different types of medicinally important molecules. Among the medicinally important indanones, the most significant drug probably is donepezil (IV), an acetylcholinesterase (AChE) inhibitor, which has been approved by the US Food and Drug Administration for the treatment of Alzheimer's disease (AD). Along with donepezil, the indanone moiety can be seen in a number of other pre-clinical and clinical candidates which belong to different categories with diverse therapeutic activities. In summary, the present review article encompasses the recent biological applications such as antialzheimer, anticancer, antimicrobial and antiviral activity of various indanone derivatives. (C) 2017 Elsevier Masson SAS. All rights reserved.
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