期刊
ORGANIC CHEMISTRY FRONTIERS
卷 8, 期 21, 页码 6074-6079出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1qo01015h
关键词
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资金
- National Natural Science Foundation of China [22078150]
- Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM)
- Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
- Top-Notch Academic Programs Project of Jiangsu Higher Education Institutions (TAPP)
The cross-coupling of cycloketone oxime esters with aldehydes catalyzed by N-heterocyclic carbenes via a radical pathway offers a modular and efficient method with easy operation and broad functional group compatibility. This method is showcased by late-stage modification of complicated aldehydes derived from medical intermediate pregnenolone and natural product diacetone-D-glucose.
A cross-coupling of cycloketone oxime esters with aldehydes catalyzed by N-heterocyclic carbenes via a radical pathway was established. This modular protocol features easy operation, no external oxidants or reductants, and a broad functional group compatibility. The merit of this method was showcased by late-stage modification of complicated aldehydes derived from the medical intermediate pregnenolone and natural product diacetone-d-glucose.
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