4.7 Review

Recent trends in nanozymes design: from materials and structures to environmental applications

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Nanozymes: A Promising Horizon for Medical and Environmental Applications

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Summary: Nanozymes are nanomaterials with high catalytic activity, stability, and cost-effective preparation, making them versatile for applications in biosensing, disease diagnosis, medical field, and environmental management. Research focuses on the types, preparation, characterization, and enzymatic activities of nanozymes, highlighting their potential in biocontrol, medical applications, and environmental pollutants detection and removal.

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Summary: The successful synthesis of noble-metal nanocrystals with controlled shapes has provided opportunities for manipulating their physicochemical properties and optimizing their advantages in various applications. Particularly in heterogeneous catalysis and surface science, the availability of these new nanomaterials has led to significant enhancements in catalytic activity and/or selectivity, as well as reduction in materials cost.

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Hui Ding et al.

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Gold Nanozymes: From Concept to Biomedical Applications

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Summary: Gold nanoparticles with enzyme-mimicking activities show great potential for applications in biomedicine, but the challenge lies in controlling their physicochemical properties and minimizing side effects for in vivo applications. Specific biorecognition elements may need to be immobilized onto nanozymes to enhance their activity, requiring further research on external parameters and toxicity studies for in vivo applicability.

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Graphitic carbon nitride (g-C3N4)-based nanostructured materials for photodynamic inactivation: Synthesis, efficacy and mechanism

Yongsheng Ni et al.

Summary: Photodynamic inactivation using graphitic carbon nitride (g-C3N4) has been widely researched for sterilization, with nanostructured materials showing great potential in enhancing its efficacy. This review systematically analyzed studies on g-C3N4-based nanostructured materials, discussing strategies, light sources, targeted organisms, and future perspectives.

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Well-dispersed Pt nanoparticles with tunable sizes on dendritic porous silica nanospheres as an artificial enzyme

Xuan Wang et al.

Summary: The study successfully utilized aminopropyl-modified dendritic porous silica nanospheres as a carrier to fabricate robust and effective nanocatalysts with small Pt nanoparticles loaded on the surface. Among them, the nanocatalyst with Pt nanoparticles sized around 2.5 nm exhibited excellent peroxidase-like catalytic activity and selectivity in a model reaction.

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A review on metal nanozyme-based sensing of heavy metal ions: Challenges and future perspectives

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Nanozymes for Environmental Pollutant Monitoring and Remediation

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Summary: Nanozymes are advanced nanomaterials that mimic natural enzymes and are ideal candidates for real-time and remote environmental monitoring and remediation due to their better structural stability. Through innovative nano-architectural design and transduction methodologies, Nanozymes have made significant progress in detecting heavy metal ions, pesticides, and organic pollutants. Strategies for remediating persistent organic pollutants are also discussed in this review.

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Summary: A novel dual-modality readout biosensing method was developed for the analysis of Cu(II), coenzyme (CoA), and histone acetyltransferase (HAT) activity. The method effectively detects and quantifies these compounds using Ru-MOF as a probe, demonstrating bidirectional detection of Cu(II) and quantification of CoA and HAT p300 activity.

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Peroxidase-like Au@Pt nanozyme as an integrated nanosensor for Ag+ detection by LSPR spectroscopy

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Effective Antibacterial Activity of Degradable Copper-Doped Phosphate-Based Glass Nanozymes

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Summary: Copper-containing antimicrobials are highly valuable in medical disinfectants due to their high antimicrobial efficacy. The Cu-PBG nanozyme exhibits excellent antibacterial effects against both Gram-positive and Gram-negative bacteria by generating a ROS storm and releasing copper ions. Being intrinsically degradable, Cu-PBG gradually degrades in vivo and releases copper ions, showing excellent biocompatibility and potential for clinical translation.

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Two-Dimensional MnO2 Nanozyme-Mediated Homogeneous Electrochemical Detection of Organophosphate Pesticides without the Interference of H2O2 and Color

Jiahui Wu et al.

Summary: In this study, manganese dioxide nanosheets were used as catalysts to develop a novel electrochemical sensor for organophosphate pesticides detection, eliminating interference from H2O2 and color. The sensor showed improved performance and lower detection limits, providing a new pathway for nanozyme-based sensors and finding more applications in food samples for OP residue determination.

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AuPeroxidase nanozymes: Promises and applications in biosensing

Bankuru Navyatha et al.

Summary: Gold nanozymes, with intrinsic catalytic activity, have emerged as a promising alternative to natural enzymes due to their ease of synthesis, surface modifications, stability, and excellent peroxidase activity. Their use in biosensing applications has seen a significant increase in recent years, with a focus on assessing peroxidase activity and detection of various analytes. Researchers have also explored the mechanisms behind the intrinsic peroxidase activity in gold nanozymes.

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Sherif A. Younis et al.

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Hollow MnFeO oxide derived from MOF@MOF with multiple enzyme-like activities for multifunction colorimetric assay of biomolecules and Hg2+

Zhiwei Lu et al.

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Yufei Wang et al.

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Sensitive colorimetric assay for the determination of alkaline phosphatase activity utilizing nanozyme based on copper nanoparticle-modified Prussian blue

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Purna K. Boruah et al.

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Guohua Jiang et al.

Summary: A peroxidase-like MOF coated magnetic surface-enhanced Raman scattering (SERS) probe was developed to detect multiple cationic dyes with good recyclability and high sensitivity. The probe, composed of Ni@Mil-100(Fe)@Ag nanowires, showed the ability to eliminate pollution molecules quickly without requiring expensive equipment. The carboxyl-functionalized Mil-100(Fe) layer on magnetic NMAs enhanced the selective enrichment of cationic dyes, leading to greatly improved sensitivity.

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Ti3C2 MXenes with intrinsic peroxidase-like activity for label-free and colorimetric sensing of proteins

Miaomiao Li et al.

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