期刊
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
卷 129, 期 -, 页码 218-250出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2017.02.031
关键词
Thiazolidinedione; PPAR gamma; Antihyperglycemic; Anticancer; Antimicrobial
Thiazolidinedione is an important heterocyclic ring system, a pharmacophore and a privileged scaffold in medicinal chemistry; is a derivative of thiazolidine ring which came into existence for its role as antihyperglycemic agent and a specific ligand of PPAR's (Peroxisome proliferator activated receptor). Exhaustive research has led to determination of its vast biological profile with wide range of therapeutic applications. This review covers recent pharmacological advancements of thiazolidinedione moiety along with structure activity relationship so as to provide better correlation among different structures and their receptor interactions. (C) 2017 Elsevier Masson SAS. All rights reserved.
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