期刊
CARDIOVASCULAR RESEARCH
卷 117, 期 10, 页码 2186-2202出版社
OXFORD UNIV PRESS
DOI: 10.1093/cvr/cvaa321
关键词
Network medicine; Precision medicine; Cardiovascular disease; Pathobiology; Omics
资金
- National Institutes of Health [HG00760, HL108630, HL119145, U01HL125215-01, 1R01HL139613-01, R01HL153502, R21HL134320, U54HL119145, T32 HL760434]
- American Heart Association [D700382, CV-19]
- Cardiovascular Medical Research Education Foundation
- Boston Biomedical Innovation Center
Network medicine views diseases as the consequences of perturbed interactions between multiple interconnected biological components, facilitating a deeper understanding of complex disease mechanisms. The limitations associated with traditional reductionist analytical methods are apparent, whereas the concept of network medicine provides a new approach to advancing cardiovascular disease research.
The ability to generate multi-omics data coupled with deeply characterizing the clinical phenotype of individual patients promises to improve understanding of complex cardiovascular pathobiology. There remains an important disconnection between the magnitude and granularity of these data and our ability to improve phenotype-genotype correlations for complex cardiovascular diseases. This shortcoming may be due to limitations associated with traditional reductionist analytical methods, which tend to emphasize a single molecular event in the pathogenesis of diseases more aptly characterized by crosstalk between overlapping molecular pathways. Network medicine is a rapidly growing discipline that considers diseases as the consequences of perturbed interactions between multiple interconnected biological components. This powerful integrative approach has enabled a number of important discoveries in complex disease mechanisms. In this review, we introduce the basic concepts of network medicine and highlight specific examples by which this approach has accelerated cardiovascular research. We also review how network medicine is well-positioned to promote rational drug design for patients with cardiovascular diseases, with particular emphasis on advancing precision medicine.
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