期刊
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
卷 127, 期 -, 页码 757-770出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2016.10.056
关键词
Hamamelitannin analogues; Scaffold hopping; MRSA; Antibiotic potentiators; Quorum sensing
资金
- Research Fund Flanders (FWO)
- Institute for the Promotion of Innovation through Science and Technology in Flanders (IWT-Vlaanderen, SBO programme)
Antimicrobial research is increasingly being focused on the problem of resistance and biofilm formation. Hamamelitannin (HAM) was recently identified as an antimicrobial potentiator for conventional antibiotics towards Staphylococcus aureus. This paper describes the synthesis and biological evaluation of novel hamamelitannin analogues with alternative central scaffolds. Via a ligand-based approach, several interesting compounds with improved synthetic accessibility were identified as potentiators for vancomycin in the treatment of MRSA infections. (C) 2016 Elsevier Masson SAS. All rights reserved.
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