Synthesis, in vitro β-glucuronidase inhibitory potential and molecular docking studies of quinolines

In this study synthesis and beta-glucuronidase inhibitory potential of 3/5/8 sulfonamide and 8-sulfonate derivatives of quinoline (1-40) are discussed. Studies reveal that all the synthetic compounds were found to have good inhibitory activity against beta-glucuronidase. Nonetheless, compounds 1, 2, 5, 13, and 22-24 having IC50 values in the range of 1.60-8.40 mu M showed superior activity than the standard saccharic acid 1,4-lactone (IC50 = 48.4 +/- 1.25 mu M). Moreover, molecular docking studies of selected compounds were also performed to see interactions between active compounds and binding sites. Structures of all the synthetic compounds were confirmed through H-1 NMR, El-MS and HREI-MS spectroscopic techniques. (C) 2017 Elsevier Masson SAS. All rights reserved.