期刊
BAGHDAD SCIENCE JOURNAL
卷 18, 期 3, 页码 575-582出版社
COLL SCIENCE WOMEN, UNIV BAGHDAD
DOI: 10.21123/bsj.2021.18.3.0575
关键词
Cloud point extraction; Determination; Ecological - friendly; Spectrophotometry; Sulfacetamide sodium
This study developed simple, low cost, precise and fast spectrophotometric methods for evaluating sulfacetamide sodium. Two different approaches were utilized, resulting in successful quantification of sulfacetamide sodium in both pure and pharmaceutical formulations.
In this study, simple, low cost, precise and speed spectrophotometric methods development for evaluation of sulfacetamide sodium are described. The primary approach contains conversion of sulfacetamide sodium to diazonium salt followed by a reaction with p-cresol as a reagent in the alkaline media. The colored product has an orange colour with absorbance at lambda max 450 nm. At the concentration range of (5.0-100 mu g.mL(-1)), the Beef s Low is obeyed with correlation coefficient (R-2= 0.9996), limit of detection as 0.2142 mu g.mL(-1), limit of quantification as 0.707 mu g.mL(-1) and molar absorptivity as 1488.249 L.mol(-1).cm(-1). The other approach, cloud point extraction was utilized to an estimation of a trace amount of the colored product in the previous procedure followed by a measuring process with a UV-Vis spectrophotometer. The linearity of the calibration graph was above the range of (1.0-60 mu g.mL(-1)), the correlation coefficient (R-2= 0.9991) and molar absorptivity was 7417.622 L.mol(-1).cm(-1). The detection limit(LOD) and quantification limit(LOQ) were based to be 0.070 and 0.231 mu g.mL(-1), respectively. This approach was successfully employed for sulfacetamide sodium detection within the pure and pharmaceutical formulation.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据