期刊
CURRENT OPINION IN BIOMEDICAL ENGINEERING
卷 19, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.cobme.2021.100312
关键词
Type 1 diabetes; Automated insulin delivery; Subpopulations; Clinical investigations
资金
- National Institutes of Health [R01DK120358, DP3DK104057, DP3DK113511, UC4DK108483]
- William K. Bowes Jr. [WKB-2020-38415]
- Leona M. and Harry B. Helmsley Charitable Trust [T1-DEXI]
This review highlights the safety and effectiveness of automated insulin delivery systems in individuals with type 1 diabetes, as well as the challenges and requirements for improving these systems for different subpopulations. Recent advances in clinical studies are also discussed.
Automated insulin delivery (AID) systems have proven safe and effective in improving glycemic outcomes in individuals with type 1 diabetes. Clinical evaluation of this technology has progressed to large randomized, controlled outpatient studies and recent commercial approval of AID systems for children and adults. However, several challenges remain in improving these systems for different subpopulations (e.g. young children, athletes, pregnant women, seniors, and those with hypoglycemia unawareness). In this review, we highlight the requirements and challenges in AID design for selected subpopulations and discuss current advances from recent clinical studies.
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