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Mast cell function in prostate inflammation, fibrosis, and smooth muscle cell dysfunction

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Summary: Bacterial infection is a known cause of prostatic inflammation, which is linked to lower urinary tract symptoms in men. A model of prostatic inflammation using Escherichia coli UTI89 infection in mice was effective in altering urinary phenotype and inducing prostate inflammation and collagen accumulation. The infection resulted in changes in bladder and prostate distribution, increased collagen density, and a unique voiding pattern in mice.

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