4.3 Review

Microbiomes and Childhood Malnutrition: What Is the Evidence?

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Summary: Human milk oligosaccharides (HMO), the third most abundant component of human milk, are believed to be crucial for infant health. This study conducted genome-wide association analyses on 395 women from 8 countries to identify genetic regions associated with different types of HMO, and found FUT2 to be the most significantly associated gene. Additionally, evidence of balancing selection for FUT2 was observed.

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Summary: Previous studies have shown that human milk composition, including HMOs, lactose, and protein, varies by geography, and these factors are associated with differences in milk and infant fecal microbial community structures. Geographic location strongly influences the microbial composition of milk and infant feces, but samples can be categorized into a smaller number of community state types based on shared microbial profiles.

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Initial Dietary and Microbiological Environments Deviate in Normal-weight Compared to Overweight Children at 10 Years of Age

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Gut microbiota of healthy and malnourished children in Bangladesh

Shirajum Monira et al.

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Early differences in fecal microbiota composition in children may predict overweight

Marko Kalliomaki et al.

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