Serum Bilirubin Levels in Overweight and Obese Individuals: The Importance of Anti-Inflammatory and Antioxidant Responses

Obesity is a chronic condition involving low-grade inflammation and increased oxidative stress; thus, obese and overweight people have lower values of serum bilirubin. Essentially, bilirubin is a potent endogenous antioxidant molecule with anti-inflammatory, immunomodulatory, antithrombotic, and endocrine properties. This review paper presents the interplay between obesity-related pathological processes and bilirubin, with a focus on adipose tissue and adipokines. We discuss potential strategies to mildly increase serum bilirubin levels in obese patients as an adjunctive therapeutic approach.

Automated summary

This review paper discusses the relationship between obesity and bilirubin, highlighting that obese patients typically have lower serum bilirubin levels as bilirubin is a potent antioxidant molecule that helps alleviate inflammation. The study also proposes potential strategies to increase serum bilirubin levels in obese patients.