4.4 Review

Frailty in inflammatory bowel diseases: an emerging concept

期刊

出版社

SAGE PUBLICATIONS LTD
DOI: 10.1177/17562848211025474

关键词

aging; Crohn's disease; frailty; geriatrics; inflammation; inflammatory bowel diseases; ulcerative colitis

资金

  1. Crohn's and Colitis Foundation Career Development Award [568735]
  2. National Institutes of Health [R03AG060169, IK2CX001800]

向作者/读者索取更多资源

Inflammatory bowel diseases are chronic conditions of the gastrointestinal tract, with a rising number of cases in older adults; older adults with IBD have poorer disease outcomes compared to younger adults; frailty is a geriatric construct that may reflect biologic age and increased vulnerability to decline across multiple physiologic systems.
Inflammatory bowel diseases (IBD), consisting of Crohn's disease and ulcerative colitis, are chronic remitting, relapsing inflammatory conditions of the gastrointestinal tract. While traditionally a disease of younger ages, the number of older adults with IBD is rising rapidly. Patients with IBD often experience geriatric syndromes at earlier ages. Older adults with IBD have poorer disease and treatment-related outcomes compared with younger adults with IBD. Applying the principles of geriatrics to understanding a chronic disease in older adults may improve health span. Better tools are needed to stratify IBD patients who are at high risk for adverse events. Frailty is a geriatric construct that may approximate biologic age. Frailty is a complex, multi-dimensional syndrome that leads to increased vulnerability to stress and decline of reserve across multiple physiologic systems. In this review, we present the leading conceptual models of frailty and discuss the applications of frailty in immune-mediated diseases. We also review chronic conditions where frailty has been applied successfully as a tool for risk stratification. Finally, we discuss in the detail the growing body of literature highlighting the relationship between frailty and IBD, the epidemiology of frailty in IBD, and ramifications of frailty in IBD.

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