4.7 Article

Balance and modulation of immunoediting for cancer treatment using synergistic nano-photo-immuno effects

期刊

NANOPHOTONICS
卷 10, 期 12, 页码 3383-3389

出版社

WALTER DE GRUYTER GMBH
DOI: 10.1515/nanoph-2021-0390

关键词

immunoediting; immunotherapy; metastatic cancers; nanotechnology; photonics; tumor microenvironment

资金

  1. U.S. National Institutes of Health [R01CA205348]
  2. Oklahoma Center for the Advancement of Science and Technology [HR16-085, HF20-019]

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The combination of nanotechnology, photonics, and immunotherapy has the potential to significantly impact the field of cancer treatment by synergizing to regulate immune editing and the immune system. By combining different treatment modalities, it can provide long-term tumor-specific immunity, preventing tumor metastasis and recurrence.
Nanotechnology, photonics, and immunotherapy are far-reaching technologies with the potential to revolutionize the field of cancer diagnostics and therapeutics. While each technology has limitations in cancer treatment, they can be synergized to exert profound impact on the balance and modulation of immunoediting in tumor microenvironment (TME) and in the entire host immune system. We provide our perspectives on how nano-photoimmuno interactions can be used as an effective therapy, particularly when combined with other treatment modalities, such as checkpoint immune therapy, chemotherapy, and TME modulation, to provide a long-term, tumor-specific immunity against tumor metastasis and tumor recurrence.

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