期刊
EMERGING INFECTIOUS DISEASES
卷 27, 期 9, 页码 2389-2398出版社
CENTERS DISEASE CONTROL & PREVENTION
DOI: 10.3201/eid2709.203349
关键词
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资金
- US National Institute of Neurologic Disorders and Stroke
- Fogarty International Center of the National Institutes of Health [R01NS080645]
- Fulbright Fellowship
This study conducted in Peru found that significant reductions in seroincidence among pigs were observed in all three intervention approaches, suggesting that multiple strategies can achieve rapid control of T. solium transmission.
Optimal control strategies for Taenia solium taeniasis and cysticercosis have not been determined. We conducted a 2-year cluster randomized trial in Peru by assigning 23 villages to 1 of 3 geographically targeted intervention approaches. For ring screening (RS), participants living near pigs with cysticercosis were screened for taeniasis; identified cases were treated with niclosamide. In ring treatment (RT), participants living near pigs with cysticercosis received presumptive treatment with niclosamide. In mass treatment (MT), participants received niclosamide treatment every 6 months regardless of location. In each approach, half the villages received targeted or mass oxfendazole for pigs (6 total study arms). We noted significant reductions in seroincidence among pigs in all approaches (67.1% decrease in RS, 69.3% in RT, 64.7% in MT; p<0.001), despite a smaller proportion of population treated by targeted approaches (RS 1.4%, RT 19.3%, MT 88.5%). Our findings suggest multiple approaches can achieve rapid control of T. solium transmission..
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