期刊
EUROPEAN JOURNAL OF HEART FAILURE
卷 20, 期 2, 页码 216-227出版社
WILEY
DOI: 10.1002/ejhf.1059
关键词
Heart failure with preserved ejection fraction; Animal models; Experimental evaluation; Molecular biology; Myocardial function
资金
- Netherlands Cardiovascular Research Initiative: 'An initiative with support of the Dutch Heart Foundation', CVON-ARENA
- Fundacao para a Ciencia e Tecnologia (financiados por fundos nacionais atraves da FCT - Fundacao para a Ciencia e Tecnologia, I.P. e cofinanciados pelo FEDER - Fundo Europeu de Desenvolvimento Regional) [PTDC/DTP-PIC/4104/2014, EXCL/BIM -MEC/0055/2012]
- Fundacao para a Ciencia e Tecnologia (atraves do COMPETE - Programa Operacional Fatores de Competitividade) [PTDC/DTP-PIC/4104/2014]
- MINOTAUR
- ERA-NET-CVD
- Diabetes obesity at the crossroads between Oncological and Cardiovascular diseases - a system analysis NET towards precision medicine (DOCnet) [NORTE-01 - 0145-FEDER-000003]
- NEw Targets in DIAstolic heart failure: from co-MOrbidities to persoNalizeD medicine (NETDIAMOND) [SAICT-PAC/0047/2015]
- EU through the European Regional Development Fund (ERDF)
- European Structural and Investment Funds (ESIF), under Lisbon Portugal Regional Operational Programme
- FCT
- [MEDIA-261409]
- British Heart Foundation [FS/13/2/29892, CH/16/3/32406, RG/16/14/32397] Funding Source: researchfish
- Fundação para a Ciência e a Tecnologia [PTDC/DTP-PIC/4104/2014] Funding Source: FCT
As heart failure with preserved ejection fraction (HFpEF) rises to epidemic proportions, major steps in patient management and therapeutic development are badly needed. With the current position paper we seek to update our view on HFpEF as a highly complex systemic syndrome, from risk factors and mechanisms to long-term clinical manifestations. We will revise recent advances in animal model development, experimental set-ups and basic and translational science approaches to HFpEF research, highlighting their drawbacks and advantages. Directions are provided for proper model selection as well as for integrative functional evaluation from the in vivo setting to in vitro cell function testing. Additionally, we address new research challenges that require integration of higher-order inter-organ and inter-cell communication to achieve a full systems biology perspective of HFpEF.
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