期刊
FOOD & FUNCTION
卷 12, 期 21, 页码 10538-10549出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1fo01509e
关键词
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资金
- National Natural Science Foundation of China [31972037]
- National Key Research and Development Project [2020YFC1606800]
- General Project of Modern Agriculture in Jiangsu Province [BE2019363]
- Key Project of Modern Agriculture in Jiangsu Province [BE2019363]
The study investigated the dopaminergic neuroprotective effects of certain phytosterols identified in rice bran and rice bran oil, showing that these phytosterols may protect dopaminergic neurons through activating signaling pathways and inhibiting apoptotic proteins. The research sheds light on a new bioactivity of different phytosterols and provides insights for the nutritional evaluation of rice bran and rice bran oil.
Phytosterols are important bioactive compounds in rice bran and rice bran oil, and the compositions of different phytosterols in rice bran and rice bran oil were investigated in our previous research. In this study, the dopaminergic neuroprotective effects and the underlying mechanisms of sitosterol, cycloartenyl ferulate, 24-methylenecycloartanyl ferulate and campesteryl ferulate identified in rice bran and rice bran oil were investigated in a rotenone-treated C. elegans model. The results indicated that the increased oxidative stress resistance induced by the activation of the DAF-16/FOXO pathway and the inhibition of the apoptotic protein CED-3 overexpression might play an important role in protecting the dopaminergic neurons. The results of this research reveal a new bioactivity of different phytosterols and are helpful for the further nutritional evaluation of rice bran and rice bran oil.
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