期刊
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
卷 49, 期 5, 页码 -出版社
SAGE PUBLICATIONS LTD
DOI: 10.1177/03000605211014094
关键词
Coagulation factor; circulating microparticle; tissue factor-bearing microparticle activity; tissue factor pathway inhibitor; thrombomodulin; disseminated intravascular coagulation; sepsis
资金
- Research and Innovation Fund for Graduate Students of Harbin Medical University [yjskycx2018-46hyd]
In patients with septic DIC, circulating MP levels are positively correlated with DIC scores and negatively correlated with coagulation factors, while TF+-MP activity is not correlated with clotting factor levels and TFPI.
Background Sepsis typically results in enhanced coagulation system activation and microthrombus formation. Microparticle (MP) production promotes coagulation and enhances pro-coagulation. This study investigated how circulating MP levels and tissue factor-bearing MP (TF+-MP) activity caused coagulation in patients with septic disseminated intravascular coagulation (DIC). Methods Thirty patients with septic DIC and 30 healthy controls were studied from December 2017 to March 2019. Patient blood samples were collected at enrolment (day 1) and on days 3 and 5; DIC scores and Sequential Organ Failure Assessment (SOFA) scores were recorded. TF+-MP activity was measured using TF-dependent factor Xa generation experiments. Circulating MP concentrations were determined by MP capture assay. Clotting factor activity, antithrombin level, soluble thrombomodulin, and serum tissue factor pathway inhibitor (TFPI) concentrations were measured. Results Patients with septic DIC had lower circulating MP levels than healthy control patients. Circulating MP levels in patients with septic DIC were positively correlated with DIC scores and negatively correlated with coagulation factors, but TF+-MP activity did not correlate with clotting factor levels and TFPI. Conclusions In patients with septic DIC, circulating MP levels are important in promoting coagulation activation and increasing clotting factor consumption. TF+-MP activity may not be the main form of active TF.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据