期刊
ANIMAL SCIENCE JOURNAL
卷 92, 期 1, 页码 -出版社
WILEY
DOI: 10.1111/asj.13640
关键词
EPAS1; FGF5; goat; high-altitude adaptation; Nepal
资金
- Institute of Animal Science and Society for Researches on Native Livestock
- JSPS [19K22367]
- Grants-in-Aid for Scientific Research [19K22367] Funding Source: KAKEN
Multiple gene polymorphisms associated with high-altitude adaptation in goats were reported in this study, where the mutant allele frequencies tended to increase with breeding altitude increase, indicating a significant contribution to high-altitude adaptation in Nepalese goat breeds.
Several studies have reported the gene polymorphisms associated with high-altitude adaptation in goats. The FGF5 gene is a regulator in the hair-growth and a SNP c.-253G>A located within 5 ' UTR has been reported to cause long-haired phenotype. The EPAS1 gene is a transcription factor for various genes that have hypoxia-adaptive functions and a nonsynonymous SNP (Q579L) located in exon 5 has been reported to be associated with the mean corpuscular hemoglobin concentration. Nepal has large difference in altitudes in the north-south direction and four indigenous goat breeds are bred depending on the altitude. We used a total of 130 animals in Nepal, Chyangra (n = 37), Sinhal (n = 24), Khari (n = 33), and Terai (n = 36), and genotyped these two gene polymorphisms to compare the gene frequencies among the breeds and investigate the associations between breeding altitudes and allele frequencies. The genotyping results revealed that the mutant allele frequency in both polymorphisms tended to increase, as the breeding altitude of each population increased. In addition, correlation coefficients showed a relatively strong positive correlation between the breeding altitude and the mutant allele frequencies (r = 0.87 in FGF5 and r = 0.68 in EPAS1). These results suggested that both polymorphisms would significantly contribute to the high-altitude adaptation in Nepalese goat breeds.
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