C-H bond functionalization by high-valent cobalt catalysis: current progress, challenges and future perspectives

Over the last decade, high-valent cobalt catalysis has earned a place in the spotlight as a valuable tool for C-H activation and functionalization. Since the discovery of its unique reactivity, more and more attention has been directed towards the utilization of cobalt as an alternative to noble metal catalysts. In particular, Cp*Co(iii) complexes, as well as simple Co(ii) and Co(iii) salts in combination with bidentate chelation assistance, have been extensively used for the development of novel transformations. In this review, we have demonstrated the existing trends in the C-H functionalization methodology using high-valent cobalt catalysis and highlighted the main challenges to overcome, as well as perspective directions, which need to be further developed in the future.

Automated summary

High-valent cobalt catalysis has become a valuable tool for C-H activation and functionalization, attracting more attention as an alternative to noble metal catalysts. The use of Cp*Co(iii) complexes and Co(ii), Co(iii) salts in combination with bidentate chelation assistance has been widely employed in the development of new transformations.