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Review
Chemistry, Medicinal
The aluminium-[18F]fluoride revolution: simple radiochemistry with a big impact for radiolabelled biomolecules
Stephen J. Archibald et al.
Summary: The [F-18]AlF radiolabelling method, which combines the favorable decay characteristics of fluorine-18 with the convenience of metal-based radiochemistry, has been widely implemented in the development of radiopharmaceuticals for the clinic. This review captures the current status of [F-18]AlF-based technology and reflects on its impact on nuclear medicine, providing insights into the future prospects of this unique radiolabelling method.
EJNMMI RADIOPHARMACY AND CHEMISTRY (2021)