Tandem Strecker/C(sp3)-H amination reactions for the construction of cyanide-functionalized imidazo[1,5-a]pyridines with NH4SCN as a cyanating agent

An I2O5 promoted tandem Strecker/C(sp(3))-H amination reaction of pyridine-2-carboxaldehydes, benzylamines and NH4SCN has been reported. This multicomponent reaction that allows the single-step construction of biologically important cyano-functionalized imidazo[1,5-a]pyridines with molecular diversity was realized for the first time. Moreover, the use of safe and easy-to-handle NH4SCN as a surrogate cyanating agent makes this protocol appealing for potential applications.

Automated summary

This multicomponent reaction successfully achieved the single-step construction of cyano-functionalized imidazo[1,5-a]pyridines with molecular diversity, with the use of NH4SCN as a safer alternative cyanating agent. The protocol shows great potential for future applications.