A robust and facile method for desulfonation to amines

In this study, a robust and facile method for desulfonation to achieve secondary amines is demonstrated. Diphenylphosphine (Ph2PH) was shown to significantly expedite the cleavage of sulfonamides under basic conditions. Aromatic and aliphatic sulfonamides were cleanly converted, with a rapid reaction time, into the required amines with good to excellent chemical yields. Moreover, the functional groups tested were generally well tolerated.

Automated summary

The study demonstrates a robust and facile method for desulfonation to achieve secondary amines, using diphenylphosphine as a catalyst. Aromatic and aliphatic sulfonamides were cleanly converted to the required amines with good to excellent chemical yields in a rapid reaction time. The functional groups tested were generally well tolerated.