期刊
DALTON TRANSACTIONS
卷 50, 期 41, 页码 14684-14694出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1dt02033a
关键词
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资金
- National Natural Science Foundation of China [21661011, 21861014]
- State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmacy, Guangxi Normal University [CMEMR2016-B13]
- Guangxi Natural Science Foundation [2016GXNSFAA380292]
- Scientific Experiment Center of Guilin Medical College, Guangxi, China
The novel chiral tetranucleate copper(ii)-based complex TNCu-A exhibits potent anti-cancer activity both in vitro and in vivo by inhibiting angiogenesis, inducing apoptosis in cells, and suppressing tumor growth.
The single crystals of two novel chiral tetranucleate copper(ii)-based complexes (TNCu-A and TNCu-B) containing l-methioninol-derived Schiff-bases were obtained. Their single structures were characterized by X-ray single crystal diffraction, infrared (IR) rays, elemental analysis, and liquid chromatography-mass spectrometry analysis. TNCu-A can effectively inhibit human umbilical vein endothelial cells (HUVECs) to form a tubular structure and it induces apoptosis of human triple-negative breast cancer MDA-MB-231 cells and HUVECs in vitro in a mitochondria dependent manner. Moreover, in vivo TNCu-A can remarkably inhibit the growth of triple-negative breast cancer from which MDA-MB-231 cells were xenografted into severely immunodeficient nude mice by inhibiting proliferation, inducing apoptosis of MDA-MB-231 cells by dramatically inhibiting the expression of the anti-apoptotic protein Bcl-2 and up-regulating the expressions of proapoptotic proteins caspase-9 and Bax, and simultaneously inhibiting tumor angiogenesis by decreasing the density of vascular endothelial cells and suppressing migration and even partially inducing apoptosis.
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