期刊
FOODS
卷 10, 期 9, 页码 -出版社
MDPI
DOI: 10.3390/foods10092000
关键词
Ishige okamurae; advanced glycation end-product; nephropathy; methylglyoxal; Nrf2/ARE pathway
资金
- National Research Foundation of Korea (NRF) - Korean government (Ministry of Science and ICT, MSIT) [NRF-2020R1A2C2012608]
- Ministry of Oceans and Fisheries, Korea
This study demonstrated that Ishige okamurae extract (IOE) possesses anti-glycation and renal protective properties by inhibiting formation of advanced glycation end-products (AGEs) in diabetic nephropathy. The bioactive compounds in IOE were found to suppress oxidative stress and apoptosis, suggesting its potential as a natural therapeutic agent for managing AGE-related nephropathy.
Advanced glycation end-products (AGEs) such as methylglyoxal (MGO) play a vital role in the pathogenesis of nephropathy, a diabetic complication. In the present study, we evaluated the anti-glycation and renal protective properties of Ishige okamurae extract (IOE) against AGE-induced oxidative stress. HPLC analysis confirmed that bioactive phlorotannins such as diphlorethohydroxycarmalol and ishophloroglucin A are predominantly present in IOE. IOE showed strong anti-glycation activities via inhibition of AGE formation, inhibition of AGE-protein cross-linking, and breaking of AGE-protein cross-links. In addition, in vitro studies using mesangial cells demonstrated that IOE effectively suppressed intracellular reactive oxygen species production, intracellular MGO accumulation, and apoptotic cell death by MGO-induced oxidative stress, in addition to regulating the expression of proteins involved in the receptor for AGEs and nuclear factor erythroid 2-related factor 2 (Nrf2)/antioxidant response elements (ARE) signaling pathways. Therefore, IOE can serve as a natural therapeutic agent for the management of AGE-related nephropathy.
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