期刊
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
卷 49, 期 5, 页码 -出版社
SAGE PUBLICATIONS LTD
DOI: 10.1177/03000605211014803
关键词
Ameloblastoma; epithelial-mesenchymal transition; single nucleotide polymorphism; HRAS; gene expression; tumor size
资金
- National Natural Science Foundation of China [81072197, 81470758, 81972535]
- Natural Science Foundation of Liaoning Province [2019-ZD-0787]
- Youth Project Foundation of Education Department of Liaoning Province [QN2019021]
Ameloblastoma is a common odontogenic epithelial tumor with various biological behaviors. Two cases of unusually large solid ameloblastomas were reported, with detected expression of epithelial-mesenchymal transition-related genes and HRAS gene single nucleotide polymorphisms, providing possible molecular evidence of mesenchymal morphological changes in ameloblastoma. Detailed analysis of these cases may deepen understanding of this rare disease and offer promising targets for future targeted therapy.
Ameloblastoma is a common odontogenic epithelial tumor that exhibits various biological behaviors, ranging from simple cystic expansion to aggressive solid masses characterized by local invasiveness, a high risk of recurrence, and even malignant transformation. We report on two cases of unusually large solid ameloblastomas. We detected epithelial-mesenchymal transition-related gene expression and HRAS gene single nucleotide polymorphisms, providing possible molecular evidence of mesenchymal morphological changes in ameloblastoma. The detailed analysis of the pathogenesis of these two cases of ameloblastoma may deepen our understanding of this rare disease and offer promising targets for future targeted therapy.
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