期刊
CURRENT SCIENCE
卷 121, 期 6, 页码 758-768出版社
INDIAN ACAD SCIENCES
DOI: 10.18520/cs/v121/i6/758-768
关键词
Host immune response; infectious diseases; pathogenicity; virulence; peptidyl-prolyl cis-trans isomerase
资金
- Department of Atomic Energy (DAE), Government of India (GoI)
- SINP, GoI
PPIases are proteins that regulate cellular processes and play a key role in microbial pathogenesis. Human PPIases not only affect viral replication but also modulate host immune response. Targeting PPIases for COVID-19 treatment may alleviate human suffering.
Peptidyl-prolyl cis-trans isomerases (PPIases) catalyse the cis-trans isomerization of C-alpha atoms about the peptide bond preceding a proline residue, thereby regulating a conformational switch which controls a plethora of cellular processes. PPIases play a key role in the survival, reproduction, proliferation and virulence of microbial pathogens vis-a-vis their human host. In addition, human PPIases either aid or retard viral replication and modulate host immune response. The article discusses the structure-function relationships of PPIases in the context of microbial virulence (with an emphasis on viruses), and on targeting PPIases for COVID-19, responsible for untold human sufferings.
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