期刊
EUROPEAN JOURNAL OF EPIDEMIOLOGY
卷 32, 期 8, 页码 691-699出版社
SPRINGER
DOI: 10.1007/s10654-017-0270-y
关键词
Glaucoma; Incidence; Optic nerve; Visual field; Intraocular pressure
资金
- Stichting Lijf en Leven, Krimpen aan de Lek in the Netherlands
- MD Fonds, Utrecht in the Netherlands
- Rotterdamse Vereniging Blindenbelangen, Rotterdam in the Netherlands
- Stichting Oogfonds Nederland, Utrecht in the Netherlands
- Blindenpenning, Amsterdam
- Blindenhulp, The Hague in the Netherlands
- Algemene Nederlandse Vereniging ter Voorkoming van Blindheid (ANVVB), Doorn in the Netherlands
- Landelijke Stichting voor Blinden en Slechtzienden, Utrecht in the Netherlands
- Swart van Essen, Rotterdam in the Netherlands
- Stichting Winckel-Sweep, Utrecht in the Netherlands
- Henkes Stichting, Rotterdam in the Netherlands
- Lameris Ootech BV, Nieuwegein in the Netherlands
- Medical Workshop, de Meern in the Netherlands
- Topcon Europe BV in the Netherlands
- Capelle aan de IJssel in the Netherlands
- Heidelberg Engineering, Dossenheim, Germany
- NWO [022.002.023]
To determine the incidence of glaucomatous visual field loss (GVFL) two decades after the start of the Rotterdam Study, and to compare known risk factors for open-angle glaucoma (OAG) between different clinical manifestations of OAG. Of 6806 participants aged 55 years and older from the population-based Rotterdam Study, 3939 underwent visual field testing at baseline and at least one follow-up round. The ophthalmic examinations included optic disc assessment and measurements of intraocular pressure (IOP), refractive error, diastolic blood pressure (DBP), and height and weight. The incidence rate of GVFL was calculated. Associations with the risk factors age, gender, baseline IOP, family history, myopia, DBP, and body-mass index [BMI] were assessed using Cox regression, with different clinical manifestations of OAG as outcome measure (glaucomatous optic neuropathy (GON), GVFL, GVFL and GON, GVFL without GON, and GON without GVFL). Median follow-up was 11.1 (IQR 6.8-17.2; range 5.0-20.3) years. The incidence rate of GVFL was 2.9 (95% confidence interval 2.4-3.4) per 1000 person years (140 cases with incident GVFL in one (n = 113) or both (n = 27) eyes). Baseline IOP and age were significantly associated with all OAG outcomes (all p < 0.001); BMI showed a non-significant protective effect in all outcomes (p = 0.01 to p = 0.09). Gender, myopia, and DBP were not associated with any outcome. Our study provides an estimate of the long-term incidence of GVFL in a predominantly white population. The development of GVFL was strongly associated with baseline IOP and age. Risk factor profiles were similar for the different outcomes.
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