期刊
EUROPEAN JOURNAL OF EPIDEMIOLOGY
卷 32, 期 8, 页码 701-710出版社
SPRINGER
DOI: 10.1007/s10654-017-0272-9
关键词
Mendelian randomization; Menarche; Puberty; Lung function; FVC; FEV1/FVC
资金
- European Union [633212]
- MRC programme Grant [G1000861]
- UK Medical Research Council [G0902125]
- Medical Research Council (MRC) [MC_PC_12010, G0501942, G0902313]
- National Institute for Health Research (NIHR)
- Academy of Finland [104781, 120315, 129269, 1114194, 24300796]
- Academy of Finland (Center of Excellence in Complex Disease Genetics and SALVE)
- University Hospital Oulu
- Biocenter
- University of Oulu, Finland [75617]
- NHLBI through the STAMPEED program [5R01HL087679-02, 1RL1MH083268-01]
- NIH/NIMH [5R01MH63706:02]
- ENGAGE Project
- EU FP7 EurHEALTHAgeing [277849]
- Medical Research Council, UK [G0500539, G0600705, G1002319]
- MRC
- Centenary Early Career Award
- DynaHEALTH action [H2020-633595]
- academy of Finland EGEA-project
- Biocentrum Helsinki
- European Commission [018996]
- Fondo de Investigacion Sanitaria [91/0016-060-05/E, 92/0319, 93/0393, 97/0035-01, 99/0034-01, 99/0034-02]
- Hospital General de Albacete
- Hospital General Ramon Jimenez
- Consejeria de Sanidad del Principado de Asturias
- CIRIT [1997SGR 00079, 1999SGR 00241]
- Servicio Andaluz de Salud
- SEPAR
- Public Health Service [R01 HL62633-01]
- RCESP [C03/09]
- Red RESPIRA [C03/011]
- Basque Health Department
- Swiss National Science Foundation
- Swiss Federal Office for Education and Science
- Swiss National Accident Insurance Fund (SUVA)
- GSF-National Research Centre for Environment and Health
- Deutsche Forschungsgemeinschaft (DFG) [FR 1526/1-1, MA 711/4-1]
- Programme Hospitalier de Recherche CliniqueDRC de Grenoble [2610]
- Ministry of Health, Direction de la Recherche Clinique
- Ministere de l'Emploi et de la Solidarite, Direction Generale de la Sante
- CHU de Grenoble
- Comite des Maladies Respiratoires de l'Isere
- UCB-Pharma (France)
- Aventis (France)
- Glaxo France
- Estonian Science Foundation
- AsthmaUK
- UK Medical Research Council
- Wellcome Trust [102215/2/13/2]
- European Union [633212]
- MRC programme Grant [G1000861]
- UK Medical Research Council [G0902125]
- Medical Research Council (MRC) [MC_PC_12010, G0501942, G0902313]
- National Institute for Health Research (NIHR)
- Academy of Finland [104781, 120315, 129269, 1114194, 24300796]
- Academy of Finland (Center of Excellence in Complex Disease Genetics and SALVE)
- University Hospital Oulu
- Biocenter
- University of Oulu, Finland [75617]
- NHLBI through the STAMPEED program [5R01HL087679-02, 1RL1MH083268-01]
- NIH/NIMH [5R01MH63706:02]
- ENGAGE Project
- EU FP7 EurHEALTHAgeing [277849]
- Medical Research Council, UK [G0500539, G0600705, G1002319]
- MRC
- Centenary Early Career Award
- DynaHEALTH action [H2020-633595]
- academy of Finland EGEA-project
- Biocentrum Helsinki
- European Commission [018996]
- Fondo de Investigacion Sanitaria [91/0016-060-05/E, 92/0319, 93/0393, 97/0035-01, 99/0034-01, 99/0034-02]
- Hospital General de Albacete
- Hospital General Ramon Jimenez
- Consejeria de Sanidad del Principado de Asturias
- CIRIT [1997SGR 00079, 1999SGR 00241]
- Servicio Andaluz de Salud
- SEPAR
- Public Health Service [R01 HL62633-01]
- RCESP [C03/09]
- Red RESPIRA [C03/011]
- Basque Health Department
- Swiss National Science Foundation
- Swiss Federal Office for Education and Science
- Swiss National Accident Insurance Fund (SUVA)
- GSF-National Research Centre for Environment and Health
- Deutsche Forschungsgemeinschaft (DFG) [FR 1526/1-1, MA 711/4-1]
- Programme Hospitalier de Recherche CliniqueDRC de Grenoble [2610]
- Ministry of Health, Direction de la Recherche Clinique
- Ministere de l'Emploi et de la Solidarite, Direction Generale de la Sante
- CHU de Grenoble
- Comite des Maladies Respiratoires de l'Isere
- UCB-Pharma (France)
- Aventis (France)
- Glaxo France
- Estonian Science Foundation
- AsthmaUK
- UK Medical Research Council
- Wellcome Trust [102215/2/13/2]
- [HEALTH-F4-2007-201413]
- Medical Research Council [G0902313, G0601361, MR/M022501/1, G0600705, G0501942, G1000861, G9815508, MC_PC_12010, G0902125, G1002319, MR/N011317/1, MC_PC_15018, MC_UU_12013/1] Funding Source: researchfish
- National Institute for Health Research [ACF-2013-21-018] Funding Source: researchfish
- MRC [G1000861, G0601361, MC_PC_12010, MR/M022501/1, G0501942, G1002319, MR/N011317/1, G0600705, MC_UU_12013/1, G0902313] Funding Source: UKRI
A trend towards earlier menarche in women has been associated with childhood factors (e.g. obesity) and hypothesised environmental exposures (e.g. endocrine disruptors present in household products). Observational evidence has shown detrimental effects of early menarche on various health outcomes including adult lung function, but these might represent spurious associations due to confounding. To address this we used Mendelian randomization where genetic variants are used as proxies for age at menarche, since genetic associations are not affected by classical confounding. We estimated the effects of age at menarche on forced vital capacity (FVC), a proxy for restrictive lung impairment, and ratio of forced expiratory volume in one second to FVC (FEV1/FVC), a measure of airway obstruction, in both adulthood and adolescence. We derived SNP-age at menarche association estimates for 122 variants from a published genome-wide meta-analysis (N = 182,416), with SNP-lung function estimates obtained by meta-analysing three studies of adult women (N = 46,944) and two of adolescent girls (N = 3025). We investigated the impact of departures from the assumption of no pleiotropy through sensitivity analyses. In adult women, in line with previous evidence, we found an effect on restrictive lung impairment with a 24.8 mL increase in FVC per year increase in age at menarche (95% CI 1.8-47.9; p = 0.035); evidence was stronger after excluding potential pleiotropic variants (43.6 mL; 17.2-69.9; p = 0.001). In adolescent girls we found an opposite effect (-56.5 mL; -108.3 to -4.7; p = 0.033), suggesting that the detrimental effect in adulthood may be preceded by a short-term post-pubertal benefit. Our secondary analyses showing results in the same direction in men and boys, in whom age at menarche SNPs have also shown association with sexual development, suggest a role for pubertal timing in general rather than menarche specifically. We found no effect on airway obstruction (FEV1/FVC).
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据